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1

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα

Xu, H. Eric, Stanley, Thomas B., Montana, Valerie G., Lambert, Millard H., Shearer, Barry G., Cobb, Jeffery E., McKee, David D., Galardi, Cristin M., Plunket, Kelli D., Nolte, Robert T.

Journal:

Year:

2002

Language:

english

File:

PDF, 377 KB

english, 2002

2

A novel dimer configuration revealed by the crystal structure at 2.4 Å resolution of human interleukin-5

Milburn, Michael V., Hassell, Anne M., Lambert, Millard H., Jordan, Steven R., Proudfoot, Amanda E. I., Graber, Pierre, Wells, Timothy N. C.

Journal:

Year:

1993

File:

PDF, 743 KB

1993

3

A Critical Assessment of Docking Programs and Scoring Functions

Warren, Gregory L., Andrews, C. Webster, Capelli, Anna-Maria, Clarke, Brian, LaLonde, Judith, Lambert, Millard H., Lindvall, Mika, Nevins, Neysa, Semus, Simon F., Senger, Stefan

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 753 KB

english, 2006

4

Crystal Structures of the Catalytic Domain of Phosphodiesterase 4B Complexed with AMP, 8-Br-AMP, and Rolipram

Robert X Xu, Warren J Rocque, Millard H Lambert, Dana E Vanderwall, Michael A Luther, Robert T Nolte

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 4.04 MB

english, 2004

5

P EROXISOME P ROLIFERATOR –A CTIVATED R ECEPTOR γ AND M ETABOLIC D ISEASE

Willson, Timothy M., Lambert, Millard H., Kliewer, Steven A.

Journal:

Annual Review of Biochemistry

Year:

2001

Language:

english

File:

PDF, 652 KB

english, 2001

6

ChemInform Abstract: Identification of a Series of Oxadiazole-Substituted α-Isopropoxy Phenylpropanoic Acids with Activity on PPARα, PPARγ, and PPARδ.

Kevin G. Liu, Jennifer S. Smith, Andrea H. Ayscue, Brad R. Henke, Millard H. Lambert, Lisa M. Leesnitzer, Kelli D. Plunket, Timothy M. Willson, Daniel D. Sternbach

Journal:

Year:

2001

File:

PDF, 34 KB

2001

7

ChemInform Abstract: Identification of a Series of PPARγ/δ Dual Agonists via Solid-Phase Parallel Synthesis.

Kevin G. Liu, Millard H. Lambert, Lisa M. Leesnitzer, William Oliver Jr., Ronda J. Ott, Kelli D. Plunket, Ludwig W. Stuart, Peter J. Brown, Timothy M. Willson, Daniel D. Sternbach

Journal:

Year:

2002

File:

PDF, 31 KB

2002

8

ChemInform Abstract: Synthesis and Biological Activity of L-Tyrosine-Based PPARγ Agonists with Reduced Molecular Weight.

Kevin G. Liu, Millard H. Lambert, Andrea H. Ayscue, Brad R. Henke, Lisa M. Leesnitzer, William R. Oliver Jr., Kelli D. Plunket, H. Eric Xu, Daniel D. Sternbach, Timothy M. Willson

Journal:

Year:

2002

File:

PDF, 32 KB

2002

9

Pattern recognition in the prediction of protein structure. II. Chain conformation from a probability-directed search procedure

Millard H. Lambert, Harold A. Scheraga

Journal:

Journal of Computational Chemistry

Year:

1989

Language:

english

File:

PDF, 1.88 MB

english, 1989

10

Pattern recognition in the prediction of protein structure. III. An importance-sampling minimization procedure

Millard H. Lambert, Harold A. Scheraga

Journal:

Journal of Computational Chemistry

Year:

1989

Language:

english

File:

PDF, 1.35 MB

english, 1989

11

Pattern recognition in the prediction of protein structure. I. Tripeptide conformational probabilities calculated from the amino acid sequence

Millard H. Lambert, Harold A. Scheraga

Journal:

Journal of Computational Chemistry

Year:

1989

Language:

english

File:

PDF, 2.75 MB

english, 1989

12

Rapid synthesis of novel dipeptide inhibitors of human collagenase and gelatinase using solid phase chemistry

Michael A. Foley, Angela S. Hassman, David H. Drewry, David G. Greer, Craig D. Wagner, Paul L. Feldman, Judd Berman, D. Mark Bickett, Gerry M. McGeehan, Millard H. Lambert, Michael Green

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 297 KB

english, 1996

13

Co-crystal structure guided array synthesis of PPARγ inverse agonists

Ryan P. Trump, Jeffrey E. Cobb, Barry G. Shearer, Millard H. Lambert, Robert T. Nolte, Timothy M. Willson, Richard G. Buckholz, Sumin M. Zhao, Lisa M. Leesnitzer, Marie A. Iannone, Kenneth H. Pearce,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 192 KB

english, 2007

14

Discovery of a novel class of PPARδ partial agonists

Barry G. Shearer, Hari S. Patel, Andrew N. Billin, James M. Way, Deborah A. Winegar, Millard H. Lambert, Robert X. Xu, Lisa M. Leesnitzer, Raymond V. Merrihew, Stephane Huet, Timothy M. Willson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 471 KB

english, 2008

15

Identification of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with activity on PPARα, PPARγ, and PPARδ

Kevin G Liu, Jennifer S Smith, Andrea H Ayscue, Brad R Henke, Millard H Lambert, Lisa M Leesnitzer, Kelli D Plunket, Timothy M Willson, Daniel D Sternbach

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

16

Identification of a series of PPARγ/δ dual agonists via solid-Phase parallel synthesis

Kevin G Liu, Millard H Lambert, Lisa M Leesnitzer, William Oliver Jr., Ronda J Ott, Kelli D Plunket, Ludwig W Stuart, Peter J Brown, Timothy M Willson, Daniel D Sternbach

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 129 KB

english, 2001

17

Synthesis and biological activity of l-tyrosine-based PPARγ agonists with reduced molecular weight

Kevin G. Liu, Millard H. Lambert, Andrea H. Ayscue, Brad R. Henke, Lisa M. Leesnitzer, William R. Oliver, Jr., Kelli D. Plunket, H.Eric Xu, Daniel D. Sternbach, Timothy M. Willson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 108 KB

english, 2001

18

Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity

Marcos L. Sznaidman, Curt D. Haffner, Patrick R. Maloney, Adam Fivush, Esther Chao, Donna Goreham, Michael L. Sierra, Christelle LeGrumelec, H.Eric Xu, Valerie G. Montana, Millard H. Lambert, Timothy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 237 KB

english, 2003

19

10.1038/25931

Milburn, Michael V., Nolte, Robert T., Wisely, G. Bruce, Westin, Stefan, Cobb, Jeffery E., Lambert, Millard H., Kurokawa, Riki, Rosenfeld, Michael G., Willson, Timothy M., Glass, Christopher K.

Journal:

Year:

1998

Language:

english

File:

PDF, 533 KB

english, 1998

20

Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction

Phelan, Caroline A, Gampe, Robert T, Lambert, Millard H, Parks, Derek J, Montana, Valerie, Bynum, Jane, Broderick, Timothy M, Hu, Xiao, Williams, Shawn P, Nolte, Robert T

Journal:

Nature Structural and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.65 MB

english, 2010

21

Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist

Mairi Sime, Amanda C. Allan, Paul Chapman, Charlotte Fieldhouse, Gerard M.P. Giblin, Mark P. Healy, Millard H. Lambert, Lisa M. Leesnitzer, Ann Lewis, Raymond V. Merrihew, Richard A. Rutter, Rosemary

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

22

Activation of Nuclear Receptors: A Perspective from Structural Genomics

Yong Li, Millard H Lambert, H.Eric Xu

Journal:

Year:

2003

Language:

english

File:

PDF, 244 KB

english, 2003

23

TACE and other ADAM proteases as targets for drug discovery

Marcia L Moss, Judith M White, Millard H Lambert, Robert C Andrews

Journal:

Drug Discovery Today

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

24

A Structural Basis for Constitutive Activity in the Human CAR/RXRα Heterodimer

Robert X. Xu, Millard H. Lambert, Bruce B. Wisely, Erin N. Warren, Emily E. Weinert, Gregory M. Waitt, Jon D. Williams, Jon L. Collins, Linda B. Moore, Timothy M. Willson, John T. Moore

Journal:

Year:

2004

Language:

english

File:

PDF, 1.15 MB

english, 2004

25

The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway

Keith D. Baker, Lisa M. Shewchuk, Tatiana Kozlova, Makoto Makishima, Annie Hassell, Bruce Wisely, Justin A. Caravella, Millard H. Lambert, Jeffrey L. Reinking, Henry Krause, Carl S. Thummel, Timothy M

Journal:

Year:

2003

Language:

english

File:

PDF, 463 KB

english, 2003

26

Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors

Robert T. Gampe Jr., Valerie G. Montana, Millard H. Lambert, Aaron B. Miller, Randy K. Bledsoe, Michael V. Milburn, Steven A. Kliewer, Timothy M. Willson, H.Eric Xu

Journal:

Year:

2000

Language:

english

File:

PDF, 754 KB

english, 2000

27

Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors

H.Eric Xu, Millard H Lambert, Valerie G Montana, Derek J Parks, Steven G Blanchard, Peter J Brown, Daniel D Sternbach, Jürgen M Lehmann, G.Bruce Wisely, Timothy M Willson, Steven A Kliewer, Michael V

Journal:

Year:

1999

Language:

english

File:

PDF, 333 KB

english, 1999

28

Structural Analysis of the Catalytic Domain of Human Fibroblast Collagenase

BRETT LOVEJOY, ANNE CLEASBY, ANNE M. HASSELL, MICHAEL A. LUTHER, DEBRA WEIGL, GERARD McGEEHAN, MILLARD H. LAMBERT, STEVEN R. JORDAN

Journal:

Annals of the New York Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 239 KB

english, 1994

29

Progesterone Receptor Ligand Binding Pocket Flexibility: Crystal Structures of the Norethindrone and Mometasone Furoate Complexes

Madauss, Kevin P., Deng, Su-Jun, Austin, Robert J. H., Lambert, Millard H., McLay, Iain, Pritchard, John, Short, Steven A., Stewart, Eugene L., Uings, Ian J., Williams, Shawn P.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 1.69 MB

english, 2004

30

Corrigendum to “Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist” [Bioorg. Med. Chem. Lett. 21 (2011) 5568–5572]

Sime, Mairi, Allan, Amanda C., Chapman, Paul, Fieldhouse, Charlotte, Giblin, Gerard M.P., Healy, Mark P., Lambert, Millard H., Leesnitzer, Lisa M., Lewis, Ann, Merrihew, Raymond V., Rutter, Richard A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 117 KB

english, 2013

31

Design of Selective and Soluble Inhibitors of Tumor Necrosis Factor-α Converting Enzyme (TACE) +

Rabinowitz, Michael H., Andrews, Robert C., Becherer, J. David, Bickett, D. Mark, Bubacz, Dulce G., Conway, James G., Cowan, David J., Gaul, Micheal, Glennon, Kimberly, Lambert, Millard H., Leesnitzer

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 453 KB

english, 2001

32

Subtype Specific Effects of Peroxisome Proliferator-Activated Receptor Ligands on Corepressor Affinity

Stanley, Thomas B., Leesnitzer, Lisa M., Montana, Valerie G., Galardi, Cristin M., Lambert, Millard H., Holt, Jason A., Xu, H. Eric, Moore, Linda B., Blanchard, Steven G., Stimmel, Julie B.

Journal:

Year:

2006

Language:

english

File:

PDF, 7 KB

english, 2006

33

Substrate Specificity in Short-Chain Phospholipid Analogs at the Active Site of Human Synovial Phospholipase A2

Wheeler, T. N., Blanchard, Steven G., Fang, Frank, Gray-Nunez, Yolanda, Harris, Cole O., Lambert, Millard H., Mehrotra, Mukund M., Parks, Derek J., Andrew, R. C.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.41 MB

english, 1994

34

Subtype Specific Effects of Peroxisome Proliferator-Activated Receptor Ligands on Corepressor Affinity

Stanley, Thomas B., Leesnitzer, Lisa M., Montana, Valerie G., Galardi, Cristin M., Lambert, Millard H., Holt, Jason A., Xu, H. Eric, Moore, Linda B., Blanchard, Steven G., Stimmel, Julie B.

Journal:

Year:

2003

Language:

english

File:

PDF, 355 KB

english, 2003

35

Spin–orbit branching in the photofragmentation of HCl at long wavelength

Lambert, H. Mark, Dagdigian, Paul J., Alexander, Millard H.

Journal:

The Journal of Chemical Physics

Year:

1998

Language:

english

File:

PDF, 400 KB

english, 1998

36

Structural Disorder in the Complex of Human Pregnane X Receptor and the Macrolide Antibiotic Rifampicin

Chrencik, Jill E., Orans, Jillian, Moore, Linda B., Xue, Yu, Peng, Li, Collins, Jon L., Wisely, G. Bruce, Lambert, Millard H., Kliewer, Steven A., Redinbo, Matthew R.

Journal:

Molecular Endocrinology

Year:

2005

Language:

english

File:

PDF, 777 KB

english, 2005

37

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

Jones, Stacey A., Moore, Linda B., Shenk, Jennifer L., Wisely, G. Bruce, Hamilton, Geraldine A., McKee, David D., Tomkinson, Nicholas C. O., LeCluyse, Edward L., Lambert, Millard H., Willson, Timothy

Journal:

Molecular Endocrinology

Year:

2000

Language:

english

File:

PDF, 1.60 MB

english, 2000

38

Substrate Specificity and Novel Selective Inhibitors of TNF-α Converting Enzyme (TACE) from Two-Dimensional Substrate Mapping

Lambert, Millard, Blackburn, R., Seaton, Theresa, Kassel, Daniel, Kinder, Daniel, Leesnitzer, M., Bickett, D., Warner, Janet, Andersen, Marc, Badiang, Jennifer, Cowan, David, Gaul, Michael, Petrov, Ki

Journal:

Combinatorial Chemistry & High Throughput Screening

Year:

2005

Language:

english

File:

PDF, 168 KB

english, 2005

39

Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors

Moore, Linda B., Maglich, Jodi M., McKee, David D., Wisely, Bruce, Willson, Timothy M., Kliewer, Steven A., Lambert, Millard H., Moore, John T.

Journal:

Molecular Endocrinology

Year:

2002

File:

PDF, 1.17 MB

2002

40

Alteration of a Single Amino Acid in Peroxisome Proliferator-Activated Receptor-α (PPARα) Generates a PPARδ Phenotype

Takada, Ichiro, Yu, Ruth T., Xu, H. Eric, Lambert, Millard H., Montana, Valerie G., Kliewer, Steven A., Evans, Ronald M., Umesono, Kazuhiko

Journal:

Molecular Endocrinology

Year:

2000

Language:

english

File:

PDF, 551 KB

english, 2000

41

Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors

Moore, Linda B., Maglich, Jodi M., McKee, David D., Wisely, Bruce, Willson, Timothy M., Kliewer, Steven A., Lambert, Millard H., Moore, John T.

Journal:

Molecular Endocrinology

Year:

2002

Language:

english

File:

PDF, 1.17 MB

english, 2002

42

Metalloproteinase Inhibitors for the Disintegrin-Like Metalloproteinases ADAM10 and ADAM17 that Differentially Block Constitutive and Phorbol Ester-Inducible Shedding of Cell Surface Molecules

Ludwig, Andreas, Hundhausen, Christian, Lambert, Millard, Broadway, Neil, Andrews, Robert, Bickett, D., Leesnitzer, M., Becherer, J.

Journal:

Combinatorial Chemistry & High Throughput Screening

Year:

2005

Language:

english

File:

PDF, 193 KB

english, 2005

43

Structural insights into regulation of nuclear receptors by ligands

Xu, Eric H., Lambert, Millard H.

Journal:

Nuclear Receptor Signaling

Year:

2003

Language:

english

File:

PDF, 4.31 MB

english, 2003

44

D3R Grand Challenge 3: blind prediction of protein–ligand poses and affinity rankings

Gaieb, Zied, Parks, Conor D., Chiu, Michael, Yang, Huanwang, Shao, Chenghua, Walters, W. Patrick, Lambert, Millard H., Nevins, Neysa, Bembenek, Scott D., Ameriks, Michael K., Mirzadegan, Tara, Burley,

Journal:

Journal of Computer-Aided Molecular Design

Year:

2019

Language:

english

File:

PDF, 3.92 MB

english, 2019